What does NAIT mean in MEDICAL

Neonatal alloimmune thrombocytopenia (NAIT) is an inherited blood disorder that affects newborns. It occurs when the mother's immune system reacts to proteins found on the baby's platelets, leading to low levels of platelets in the baby's bloodstream.

Women who have previously had a baby with NAIT and women who are Rh-negative are at increased risk of having a baby with NAIT. A father's genetic background can also increase a baby's risk of having NAIT.

The most common symptom of NAIT is bleeding or bruising in areas of trauma, such as around injection sites or after circumcision. Other symptoms may include jaundice, petechiae (red spots on skin), and paleness or pallor due to anemia. Bleeding from umbilical cord stump or gastrointestinal tract can also occur.

Diagnosis begins with a physical exam and review of your medical history and that of your family members; special tests may be needed such as a CBC (complete blood count) with differential, liver function tests, immunology tests and other evaluations to rule out infection. Platelet antibodies may then be tested if indicated by results of other testing.

Treatment for babies born with NAIT usually involves decreasing exposure to antigens in utero through administration of intravenous Immunoglobulin (IVIG). Depending upon severity, management may involve exchange transfusion or intrauterine transfusions if needed. Treatment often involves management with high doses of steroids and careful monitoring for bleeding episodes until platelet levels return back to normal range post-delivery but babies may need lifelong follow up for any associated immunological impairments which could have long term health implications including recurrent infections over time and even autoimmune problems like ITP later in life..