What does AAV mean in MEDICAL
Adenovirus-associated virus, or AAV, is a type of virus that is closely related to adenoviruses. AAV can cause mild symptoms such as common colds in humans and is associated with diseases such as asthma, cervical cancer, and respiratory infections. AAV is also used as a tool for gene therapy because it can be easily modified genetically to deliver therapeutic genes into cells. In this article, we will discuss the structure and functions of AAV and its implications for gene therapy.
AAV meaning in Medical in Medical
AAV mostly used in an acronym Medical in Category Medical that means Adenovirus-associated virus
Shorthand: AAV,
Full Form: Adenovirus-associated virus
For more information of "Adenovirus-associated virus", see the section below.
Properties of the Virus
AAV belongs to the family Parvoviridae and is a non-enveloped virus composed of an icosahedral capsid containing a single-stranded linear DNA genome. The genetic material consists of only 4 kb in length and lacks enzymes essential for viral replication making it highly dependent on the host cell machinery. Interestingly, although not able to replicate within a host cell, AAV does integrate its genome into the chromosome of infected cells which makes it a powerful tool for gene therapy applications.
Applications in Gene Therapy
Due to its limited size and ability to integrate into the genome of many species including humans, AAV has excellent properties for gene therapy strategies. It can deliver genes with high efficiency over large areas due to its high infectivity rates. The integration property facilitates long term expression of desired genes which makes it ideal for targeted therapies where sustained levels of transgenes are required. Additionally, recent studies have focused on using this virus vector to target tumors by expressing tumor suppressor proteins or anti-angiogenetic factors while sparing normal tissues by manipulating specific promoters accordingly.
Essential Questions and Answers on Adenovirus-associated virus in "MEDICAL»MEDICAL"
AAV-based gene delivery systems offer promise in terms of effective delivery combined with long term expression capability, therefore promising potential therapeutic applications against various diseases such as cancer and genetic disorders. This system has proven successful at delivering functional genes to cells in preclinical models which opens up doors for human clinical trials in the near future all while providing novel insights into how we view gene therapy treatments.
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